Differential proteomic analysis of the reactivated p53 via Nutlin-3a, in 3 different types of human lymphomas

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http://hdl.handle.net/10795/3319
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Abstract	Purpose: The identification and quantification of protein expression levels of nutlin-3A-induced p53 stabilization and activation in human lymphoma. Methods: The Isotope Coded Protein Label (ICPL) technique was followed by nano-Liquid Chromatography coupled on-line with Mass Spectrometry (nLC-MS/MS). Results: Reliable identification & differential quantitative determination of human lymphoma proteome profile, revealing alterations in the HSPs relative expression levels.
Author/Creator	Psatha, Konstantina; Drakos, Elias; Rassidakis, George Z.; Aivaliotis, Michalis
Contractor	Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
Publisher	Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
Language	English
Date	October 2011
Extent	1 pages
Subject	βιολογία κυτταρολογία επιδημιολογία
Keywords	Human lymphomas, Proteomic analysis, p53, Protein nutlin-3a, Isotope coded protein label, HSPs
Type	Text (Conference or workshop item (Poster))
Scientific Coordinator	Πατσούρης, Ευστράτιος
Project Notes	Τίτλος Πράξης: Γενωμική και πρωτεωμική ανάλυση της επαγωγής του ογκοκατασταλτικου γονιδίου Ρ53 σε HODGKIN και μη-HODGKIN λεμφώματα. Τίτλος Δράσης: Ηράκλειτος ΙΙ