eng URI http://hdl.handle.net/10795/3052 water treatment hazardous waste water pollution sewage sludge Pharmaceuticals are continuously discarded Pharmaceuticals are continuously discarded into the aquatic system through wastewater treatment plants (WWTPs). The microbial degradation of these organic micropollutants and formation of transformation products (TPs) under aerobic conditions is the fundamental process for their elimination. It is of paramount importance to understand the microbial metabolic pathways so as to obtain knowledge of how fast micropollutants degraded and to assess the exposure to their potential TPs as they can be more polar and consequently environmentally persistent. In this study, batch reactors seeded with activated sludge from the WWTP of Athens were set up to assess biotic, abiotic and sorption losses of selective psychotropic drugs, containing amine moieties. Biodegradation and transformation products were identified using liquid chromatography quadrupole-time-offlight mass spectrometry (LC-QToF-MS). A workflow for target, suspect and non-target screening was developed. Data treatment was performed by using metabolite tools accompanying Bruker’s maxis impact ESI-QToF-MS and the structure elucidation of the candidate transformation products was based on accurate mass and isotopic pattern measurements by HRMS and tentative interpretation of MS/MS spectra. Finally four biotransformation products were identified for both lidocaine and ephedrine. Despite the structure similarities, different degradation constants were calculated for each compound. 1 pp. LOMv1.0 creator LOMv1.0subject matter expert LOMv1.0 Project Final Beneficiary LOMv1.0 Project Executing Organisation 2014 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text Aquatic environment Biodegradation Emerging pollutant Wastewater treatment plants Pharmaceuticals Transformation products 4530496 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/3052/2/3052_121B%23JMD.pdf URI http://hdl.handle.net/10795/3052 LOMv1.0creator 2016-05-09T08:31:29Z LOMv1.0validator 2016-05-09T08:31:29Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")