eng URI http://hdl.handle.net/10795/3588 καρκίνος DNA ανοσολογία The characteristic feature of healthy living organisms is the preservation of homeostasis. Compelling evidence highlight that the DNA damage response and repair (DDR/R) and immune response (ImmR) signaling networks work together favoring the harmonized function of (multi)cellular organisms. DNA and RNA viruses activate the DDR/R machinery in the host cells both directly and indirectly. Activation of DDR/R in turn favors the immunogenicity of the incipient cell. Hence, stimulation of DDR/R by exogenous or endogenous insults triggers innate and adaptive ImmR. The immunogenic properties of ionizing radiation, a prototypic DDR/R inducer, serve as suitable examples of how DDR/R stimulation alerts host immunity. Thus, critical cellular danger signals stimulate defense at the systemic level and vice versa. Disruption of DDR/R–ImmR cross talk compromises (multi)cellular integrity, leading to cell-cycle-related and immune defects. The emerging DDR/R–ImmR concept opens up a new avenue of therapeutic options, recalling the Hippocrates quote “everything in excess is opposed by nature.” 25 pp. LOMv1.0 creator LOMv1.0 publisher LOMv1.0 Scientific Coordinator LOMv1.0 Project Executing Organisation 2015 Digital Library of the Operational Programme "Education and Lifelong Learning" abstract types Text DNA damage response and repair machinery Immune response Pattern recognition receptors Inflammation Cancer Autoimmunity http://www.sciencedirect.com/science/article/pii/S0163725815001382 4056639 application/pdf http://repository.edulll.gr/edulll/bitstream/10795/3588/2/3588_1.149_%ce%94%ce%97%ce%9c_3_7_15.pdf URI http://hdl.handle.net/10795/3588 LOMv1.0creator 2016-06-08T07:57:23Z LOMv1.0validator 2016-06-08T07:57:23Z LOMv1.0 gre no no Copyright EYD-EPEDBM (Operational Programme "Education and Lifelong Learning")