Modeling, substrate docking, and mutational analysis
identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter
Please use any of these identifiers to cite or link to this item: http://hdl.handle.net/10795/3230 http://repository.edulll.gr/3230
Background: The purine-cytosine FcyB transporter is a prototype member of the NCS1 family. Results: Using homology modeling, substrate docking, and rational mutational analysis, we identify residues critical for function and specificity. Conclusion: Important aspects concerning the molecular mechanism and evolution of transporter specificity are revealed. Significance: The first systematic approach on structure-function-specificity relationships in a eukaryotic NCS1 member is shown.
